Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis

Table 2 PBMC subpopulations for which significant differences existed between the controls, patients with JIA other than sJIA, and patients with systemic arthritis

PBMC subpopulation	Percentage of PBMC				Pairwise multiple comparison
	1. Controls	2. non-sJIA	3. sJIA	ANOVA	1. vs. 2.	1. vs. 3.	2. vs. 3.
CD3^-CD56⁺	6.1 ± 3.9	7.4 ± 4.0	4.7 ± 1.7	0.02	NS	NS	< 0.05
CD56⁺ dim	5.5 ± 3.5	6.7 ± 3.9	3.7 ± 1.4	0.009	NS	NS	< 0.05
CD15⁺CD16^-	0.05 ± 0.03	0.06 ± 0.05	0.18 ± 0.19	< 0.001	NS	< 0.05	< 0.05
CD8⁺CD25⁺	0.46 ± 0.26	0.78 ± 0.60	0.70 ± 0.40	0.005	< 0.05	NS	NS
CD19⁺	16.8 ± 6.6	13.2 ± 5.8	11.7 ± 6.6	0.002	< 0.05	< 0.05	NS
CD34⁺	0.08 ± 0.04	0.08 ± 0.05	0.16 ± 0.11	< 0.001	NS	< 0.05	< 0.05
CD34⁺CD33^-	0.05 ± 0.03	0.06 ± 0.04	0.11 ± 0.09	< 0.001	NS	< 0.05	< 0.05
CD34⁺CD33⁺	0.03 ± 0.02	0.02 ± 0.02	0.05 ± 0.03	< 0.001	< 0.05	NS	< 0.05
NK bright/dim ratio	0.14 ± 0.09	0.13 ± 0.12	0.28 ± 0.16	< 0.001	NS	< 0.05	< 0.05
CD4:CD8 ratio	2.20 ± 0.7	2.14 ± 0.7	2.81 ± 0.9	0.006	NS	< 0.05	< 0.05

Differences were analyzed with one-way ANOVA followed by Tukey's pairwise multiple comparison, assuming a significance level of P < 0.05. PBMCs, peripheral blood mononuclear cells; JIA, juvenile idiopathic arthritis; sJIA, systemic JIA; non-sJIA, JIA other than sJIA.

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