Concentrations of IL-6, IL-8, IL-10 and TNF-α. Intraarticular (left panel) and peri-synovial (right panel) concentrations in the NEx and Ex groups at T1 and T2. Each point represents a mean (when run in duplicate) of the measured values and each connecting line represents a subject with before/after values. IL-10 increased significantly in the Ex group in both compartments (*P < 0.05), but remained stationary in the NEx group. Significant increases regardless of exercise are seen for IL-6 and IL-8 in both positions and also for TNF-α intraarticularly (*P < 0.05), whereas TNF-α increased peri-synovially in the Ex group but not in the Ex group. (i.a., intraarticular; syn, peri-synovial).