TY - JOUR AU - Griffin, Timothy M. AU - Fermor, Beverley AU - Huebner, Janet L. AU - Kraus, Virginia B. AU - Rodriguiz, Ramona M. AU - Wetsel, William C. AU - Cao, Li AU - Setton, Lori A. AU - Guilak, Farshid PY - 2010 DA - 2010/07/06 TI - Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice JO - Arthritis Research & Therapy SP - R130 VL - 12 IS - 4 AB - Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood, but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral, inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. SN - 1478-6354 UR - https://doi.org/10.1186/ar3068 DO - 10.1186/ar3068 ID - Griffin2010 ER -