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Table 4 Functional classification of genes modulated by iloprost in SSc patients with digital ulcers

From: Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion

Probe set ID Gene Title Gene symbol F.C. SSc ulcers/healthy F.C. SSc ulcers post-treatment/SSc ulcers pre-treatment Representative Public ID
Positive regulation of anti-apoptosis
210621_s_at RAS p21 protein activator (GTPase activating protein) 1 RASA1 8.72 down 4.28 up M23612
214917_at protein kinase, AMP-activated, alpha 1 catalytic subunit PRKAA1 6.49 down 6.60 up AK024252
201849_at BCL2/adenovirus E1B 19 kDa interacting protein 3 BNIP3 69.04 down 11.78 up NM_004052
Response to stress
200985_s_at CD59 molecule, complement regulatory protein CD59 18.76 down 2.72 up NM_000611
202906_s_at nibrin NBN 12.38 down 4.28 up AF049895
206040_s_at mitogen-activated protein kinase 11 MAPK11 17.27 up 10.62 down NM_002751
209305_s_at growth arrest and DNA-damage-inducible. beta GADD45B 13.58 down 8.27 down AF078077
210512_s_at vascular endothelial growth factor VEGF 36.08 down 5.58 up AF022375
213756_s_at heat shock transcription factor 1 HSF1 8.12 up 3.47 down AI393937
217684_at thymidylate synthetase TYMS 4.21 down 3.30 up BG281679
220038_at serum/glucocorticoid regulated kinase family. member 3 SGK3 8.24 down 9.60 down NM_013257
Response to wounding and wound healing
209277_at Tissue factor pathway inhibitor 2 TFPI2 9.85 down 2.62 up AL574096
203294_s_at lectin, mannose-binding, 1 LMAN1 11.53 up 9.84 down U09716
205767_at epiregulin EREG 5.13 down 3.61 down NM_001432
209101_at connective tissue growth factor CTGF 595.44 down 14.43 up M92934
Wnt receptor activity
203987_at frizzled homolog 6 FZD6 39.71 down 2.18 up NM_003506
Receptor complex
201474_s_at integrin. alpha 3 ITGA3 5.21 down 2.36 up NM_002204
204625_s_at integrin. beta 3 ITGB3 2.17 up 2.47 down BF115658
206009_at integrin. alpha 9 ITGA9 3.18 down 3.58 down NM_002207
211772_x_at cholinergic receptor. nicotinic. alpha 3 CHRNA3 2.54 up 4.46 down BC006114
204773_at interleukin 11 receptor. alpha IL11RA 15.25 down 2.90 down NM_004512
membrane
202637_s_at intercellular adhesion molecule 1 (CD54) ICAM1 28.90 down 6.61 up AI608725
203699_s_at deiodinase, iodothyronine, type II DIO2 7.75 up 10.10 down U53506
203988_s_at fucosyltransferase 8 (alpha (1,6) fucosyltransferase) FUT8 17.44 down 17.71 up NM_004480
204273_at endothelin receptor type B EDNRB 10.11 up 2.75 down NM_000115
205421_at solute carrier family 22, member 3 SLC22A3 6.50 up 6.21 down NM_021977
213856_at CD47 molecule CD47 12.43 down 10.98 up BG230614
Chemotaxis
205242_at chemokine (C-X-C motif) ligand 13 CXCL13 3.03 down 7.56 up NM_006419
209687_at chemokine (C-X-C motif) ligand 12 CXCL12 24.98 down 2.54 up U19495
210845_s_at plasminogen activator, urokinase receptor PLAUR 12.79 down 2.05 up U08839
207850_at chemokine (C-X-C motif) ligand 3 CXCL3 24.57 down 3.15 down NM_002090
210163_at chemokine (C-X-C motif) ligand 11 CXCL11 34.76 down 5.60 up AF030514
215723_s_at phospholipase D1, phosphatidylcholine-specific PLD1 12.37 down 3.08 up AJ276230
219825_at cytochrome P450, family 26, subfamily B, polypeptide 1 CYP26B1 17.74 down 15.25 up NM_019885
DNA-dependent DNA replication
205085_at origin recognition complex, subunit 1-like ORC1L 10.43 down 7.25 up NM_004153
208070_s_at REV3-like, catalytic subunit of DNA polymerase zeta REV3L 38,90 down 2.80 down NM_002912
208808_s_at high-mobility group box 2 HMGB2 5.53 down 2.41 up BC000903
209084_s_at RAB28, member RAS oncogene family RAB28 23.27 down 2.09 up BE504689
210892_s_at general transcription factor II, i GTF2I 3.72 down 3.64 up BC004472
DNA-dependent DNA replication
205085_at carbonyl reductase 1 CBR1 2.39 up 2.34 down BC002511
G0 to G1 transition
205655_at Mdm4, p53 binding protein MDM4 3.27 down 6.07 up NM_002393
platelet-derived growth factor beta-receptor activity
205226_at platelet-derived growth factor receptor-like PDGFRL 5.33 up 9.50 down NM_006207
actin cytoskeleton organization and biogenesis
209209_s_at pleckstrin homology domain containing, family C, member1 PLEKHC1 51.02 down 13.59 up AW469573
216621_at Rho-associated, coiled-coil containing protein kinase 1 ROCK1 8.58 down 8.52 up AL050032
220997_s_at diaphanous homolog 3 (Drosophila) DIAPH3 3.72 down 10.53 up NM_030932
208614_s_at filamin B, beta (actin binding protein 278) FLNB 59.49 down 2.91 down M62994
214925_s_at spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) SPTAN1 13.23 down 2.62 down AK026484
215602_at FYVE, RhoGEF and PH domain containing 2 FGD2 12.94 up 2.60 down AK024456
Innate immune response
204924_at toll-like receptor 2 TLR2 5.94 down 3.16 up NM_003264
206271_at toll-like receptor 3 TLR3 55.81 down 6.59 down NM_003265
206206_at CD180 molecule CD180 23.53 down 10.73 up NM_005582
210166_at toll-like receptor 5 TLR5 27.49 down 2.03 up AF051151
215388_s_at complement factor H CFH 561.66 down 2.36 down X56210
206157_at pentraxin-related gene, rapidly induced by IL-1 beta PTX3 5.17 down 12.45 up NM_002852
206693_at interleukin 7 IL7 3.06 down 11.97 up NM_000880
206727_at complement component 9 C9 6.43 up 9.24 down K02766
  1. SSc, progressive systemic sclerosis