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Table 5 Functional classification of genes modulated by iloprost in SSc patients without digital ulcers

From: Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion

Probe Set ID Gene Title Gene symbol FC SSc/healthy FC SSc post-treatment/SSc pre-treatment Representative Public ID
Positive regulation of anti-apoptosis
201849_at BCL2/adenovirus E1B 19 kDa interacting protein 3 BNIP3 19.65 down 5.93 up NM_004052
210621_s_at RAS p21 protein activator (GTPase activating protein) 1 RASA1 5.35 down 2.02 up M23612
214917_at protein kinase, AMP-activated, alpha 1 catalytic subunit PRKAA1 2.88 down 3.50 up AK024252
Response to stress
202906_s_at nibrin NBN 3.83 down 4.33 up AF049895
206040_s_at mitogen-activated protein kinase 11 MAPK11 3.53 up 2.15 up NM_002751
209305_s_at growth arrest and DNA-damage-inducible, beta GADD45B 11.23 down 4.25 up AF078077
210512_s_at vascular endothelial growth factor VEGF 7.03 down 2.38 up AF022375
217684_at thymidylate synthetase TYMS 2.76 down 5.84 up BG281679
Response to wounding and wound healing
209101_at connective tissue growth factor CTGF 1912.1 down 11.18 up M92934
209277_at Tissue factor pathway inhibitor 2 TFPI2 3.36 down 8.90 down AL574096
Wnt receptor activity
203987_at frizzled homolog 6 FZD6 19.85 down 3.25 up NM_003506
Receptor complex
201474_s_at integrin, alpha 3 ITGA3 3.37 down 2.04 up NM_002204
206009_at integrin, alpha 9 ITGA9 2.05 down 2.02 up NM_002207
211772_x_at cholinergic receptor, nicotinic, alpha 3 CHRNA3 2.10 up 12.73 down BC006114
204773_at interleukin 11 receptor, alpha IL11RA 10.76 down 6.66 up NM_004512
Membrane
202638_s_at intercellular adhesion molecule 1 (CD54) ICAM1 21.89 down 2.00 up NM_000201
204273_at endothelin receptor type B EDNRB 12.18 up 9.07 up NM_000115
205421_at solute carrier family 22, member 3 SLC22A3 14.37 up 8.31 down NM_021977
213857_s_at CD47 molecule CD47 6.17 down 3.51 up BG230614
Chemotaxis
207850_at chemokine (C-X-C motif) ligand 3 CXCL3 35.50 down 2.32 up NM_002090
211122_s_at chemokine (C-X-C motif) ligand 11 CXCL11 2.98 down 2.32 down AF002985
215723_s_at phospholipase D1, phosphatidylcholine-specific PLD1 7.72 down 2.07 up AJ276230
219825_at cytochrome P450, family 26, subfamily B, polypeptide 1 CYP26B1 25.09 down 3.98 down NM_019885
203218_at mitogen-activated protein kinase 9 MAPK9 9.53 down 7.02 up W37431
DNA-dependent DNA replication
208070_s_at REV3-like, catalytic subunit of DNA polymerase zeta REV3L 21.36 down 8.90 up NM_002912
208808_s_at high-mobility group box 2 HMGB2 2.78 down 3.18 up BC000903
209084_s_at RAB28, member RAS oncogene family RAB28 7.25 down 3.79 up BE504689
213336_at General transcription factor II, i GTF2I 4.51 down 4.52 up AI826454
Prostaglandin-E2 9-reductase activity
50221_at transcription factor EB TFEB 6.09 down 11.09 up AI524138
G0 to G1 transition
210386_s_at metaxin 1 MTX1 6.35 down 4.85 up BC001906
platelet-derived growth factor beta-receptor activity
205226_at platelet-derived growth factor receptor-like PDGFRL 5.04 up 2.72 up NM_006207
actin cytoskeleton organization and biogenesis
208614_s_at filamin B, beta (actin binding protein 278) FLNB 92.27 down 2.75 up M62994
214925_s_at spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) SPTAN1 17.80 down 8.95 up AK026484
215602_at FYVE, RhoGEF and PH domain containing 2 FGD2 15.22 down 5.67 up AK024456
Innate immune response
206271_at toll-like receptor 3 TLR3 8.66 down 10.24 down NM_003265
210166_at toll-like receptor 5 TLR5 7.83 down 2.95 up AF051151
215388_s_at complement factor H CFH 295.64 down 3.15 down X56210
206693_at interleukin 7 IL7 10.94 down 2.96 up NM_000880
203854_at complement factor I CFI 578.23 down 16.50 up NM_000204
206727_at complement component 9 C9 11.81 down 10.01 up K02766
  1. SSc, progressive systemic sclerosis