Table 5 Functional classification of genes modulated by iloprost in SSc patients without digital ulcers
Probe Set ID | Gene Title | Gene symbol | FC SSc/healthy | FC SSc post-treatment/SSc pre-treatment | Representative Public ID |
|---|---|---|---|---|---|
Positive regulation of anti-apoptosis | |||||
201849_at | BCL2/adenovirus E1B 19 kDa interacting protein 3 | BNIP3 | 19.65 down | 5.93 up | NM_004052 |
210621_s_at | RAS p21 protein activator (GTPase activating protein) 1 | RASA1 | 5.35 down | 2.02 up | M23612 |
214917_at | protein kinase, AMP-activated, alpha 1 catalytic subunit | PRKAA1 | 2.88 down | 3.50 up | AK024252 |
Response to stress | |||||
202906_s_at | nibrin | NBN | 3.83 down | 4.33 up | AF049895 |
206040_s_at | mitogen-activated protein kinase 11 | MAPK11 | 3.53 up | 2.15 up | NM_002751 |
209305_s_at | growth arrest and DNA-damage-inducible, beta | GADD45B | 11.23 down | 4.25 up | AF078077 |
210512_s_at | vascular endothelial growth factor | VEGF | 7.03 down | 2.38 up | AF022375 |
217684_at | thymidylate synthetase | TYMS | 2.76 down | 5.84 up | BG281679 |
Response to wounding and wound healing | |||||
209101_at | connective tissue growth factor | CTGF | 1912.1 down | 11.18 up | M92934 |
209277_at | Tissue factor pathway inhibitor 2 | TFPI2 | 3.36 down | 8.90 down | AL574096 |
Wnt receptor activity | |||||
203987_at | frizzled homolog 6 | FZD6 | 19.85 down | 3.25 up | NM_003506 |
Receptor complex | |||||
201474_s_at | integrin, alpha 3 | ITGA3 | 3.37 down | 2.04 up | NM_002204 |
206009_at | integrin, alpha 9 | ITGA9 | 2.05 down | 2.02 up | NM_002207 |
211772_x_at | cholinergic receptor, nicotinic, alpha 3 | CHRNA3 | 2.10 up | 12.73 down | BC006114 |
204773_at | interleukin 11 receptor, alpha | IL11RA | 10.76 down | 6.66 up | NM_004512 |
Membrane | |||||
202638_s_at | intercellular adhesion molecule 1 (CD54) | ICAM1 | 21.89 down | 2.00 up | NM_000201 |
204273_at | endothelin receptor type B | EDNRB | 12.18 up | 9.07 up | NM_000115 |
205421_at | solute carrier family 22, member 3 | SLC22A3 | 14.37 up | 8.31 down | NM_021977 |
213857_s_at | CD47 molecule | CD47 | 6.17 down | 3.51 up | BG230614 |
Chemotaxis | |||||
207850_at | chemokine (C-X-C motif) ligand 3 | CXCL3 | 35.50 down | 2.32 up | NM_002090 |
211122_s_at | chemokine (C-X-C motif) ligand 11 | CXCL11 | 2.98 down | 2.32 down | AF002985 |
215723_s_at | phospholipase D1, phosphatidylcholine-specific | PLD1 | 7.72 down | 2.07 up | AJ276230 |
219825_at | cytochrome P450, family 26, subfamily B, polypeptide 1 | CYP26B1 | 25.09 down | 3.98 down | NM_019885 |
203218_at | mitogen-activated protein kinase 9 | MAPK9 | 9.53 down | 7.02 up | W37431 |
DNA-dependent DNA replication | |||||
208070_s_at | REV3-like, catalytic subunit of DNA polymerase zeta | REV3L | 21.36 down | 8.90 up | NM_002912 |
208808_s_at | high-mobility group box 2 | HMGB2 | 2.78 down | 3.18 up | BC000903 |
209084_s_at | RAB28, member RAS oncogene family | RAB28 | 7.25 down | 3.79 up | BE504689 |
213336_at | General transcription factor II, i | GTF2I | 4.51 down | 4.52 up | AI826454 |
Prostaglandin-E2 9-reductase activity | |||||
50221_at | transcription factor EB | TFEB | 6.09 down | 11.09 up | AI524138 |
G0 to G1 transition | |||||
210386_s_at | metaxin 1 | MTX1 | 6.35 down | 4.85 up | BC001906 |
platelet-derived growth factor beta-receptor activity | |||||
205226_at | platelet-derived growth factor receptor-like | PDGFRL | 5.04 up | 2.72 up | NM_006207 |
actin cytoskeleton organization and biogenesis | |||||
208614_s_at | filamin B, beta (actin binding protein 278) | FLNB | 92.27 down | 2.75 up | M62994 |
214925_s_at | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | SPTAN1 | 17.80 down | 8.95 up | AK026484 |
215602_at | FYVE, RhoGEF and PH domain containing 2 | FGD2 | 15.22 down | 5.67 up | AK024456 |
Innate immune response | |||||
206271_at | toll-like receptor 3 | TLR3 | 8.66 down | 10.24 down | NM_003265 |
210166_at | toll-like receptor 5 | TLR5 | 7.83 down | 2.95 up | AF051151 |
215388_s_at | complement factor H | CFH | 295.64 down | 3.15 down | X56210 |
206693_at | interleukin 7 | IL7 | 10.94 down | 2.96 up | NM_000880 |
203854_at | complement factor I | CFI | 578.23 down | 16.50 up | NM_000204 |
206727_at | complement component 9 | C9 | 11.81 down | 10.01 up | K02766 |