Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate

Table 3 Correlations between brain metabolites that show significant differences between both groups and psychological variables

Metabolite	HADS-anx	HADS-dep	PVAS	Sphigm	MMSE	Catastroph	FIQ
Posterior cingulate gyrus Glx
(Coefficient)	0.43	0.44	0.37	-0.45	0.39	0.40	0.45
(P value)	0.057	0.047^a	0.107	-0.047^a	0.089	0.081	0.043^a
Posterior cingulate gyrus Glx/Cr ratio
(Coefficient)	0.42	0.47	0.39	-0.50	0.36	0.40	0.55
(P value)	0.062	0.034^a	0.08	-0.024^a	0.117	0.077	0.011^a

^aP < 0.05.
Catastroph, Pain catastrophization scale; FIQ, Fibromyalgia Impact Questionnaire; Glx, glutamate+glutamine; Glx/Cr, glutamate+glutamine/creatine ratio; HADS-Anx, Hospital Anxiety Depression Scale, subscale anxiety; HADS-Dep, Hospital Anxiety Depression Scale, subscale depression; MMSE, Mini Mental State Examination; PVAS, Pain Visual Analogue Scale; Sphigm, pain threshold assessed by sphygmomanometer (the pressure that is needed to evoke pain).

ISSN: 1478-6362