TY - JOUR AU - Alsaleh, Ghada AU - Sparsa, Laetitia AU - Chatelus, Emmanuel AU - Ehlinger, Mathieu AU - Gottenberg, Jacques-Eric AU - Wachsmann, Dominique AU - Sibilia, Jean PY - 2010 DA - 2010/07/08 TI - Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis JO - Arthritis Research & Therapy SP - R135 VL - 12 IS - 4 AB - Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-8. The expression of this cytokine is highly increased in the rheumatoid synovium and correlated with the severity of joint inflammation. Little is known regarding the innate immune-related regulation of IL-32 by fibroblast-like synoviocytes (FLSs). We therefore investigated the effect of innate immune stimulation by ligands of Toll-like receptor (TLR)2, TLR3, and TLR4, and cytokines such as TNF-α and interferon (IFN)-γ, on IL-32 expression by FLSs. SN - 1478-6354 UR - https://doi.org/10.1186/ar3073 DO - 10.1186/ar3073 ID - Alsaleh2010 ER -