Figure 2
Adenoviral-mediated gene transfer in joints of live mice. Two mice were injected with 10 μl of adenoviral particles (1 × 107 plaque forming units) expressing luciferase into each of the hind ankle joints. At various time points, the mice were injected intraperitoneally with luciferin, and expression of the transgene (luciferase) detected by bioluminescent imaging at one hour after administration of luciferin. The injected joints clearly showed the expression of luciferase, as indicated by the green luminescent color and the expression of luciferase could be detected as late as 18 days post injection.