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Table 2 Relationship between BMI (kg/m2), and cartilage properties and bone marrow lesions in the tibiofemoral compartment

From: Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?

  Univariate analysis n = 142 P value Multivariate analysisan = 142 P value Multivariate analysisbn = 129 P value
Cartilage volume (ml)
Current BMI -4.20 (-14.58, 6.18)1 0.42 -6.98 (-16.98, 3.02)2 0.17 -7.73 (-18.55, 3.09)2 0.16
Baseline BMI -0.60 (-13.51, 12.32)1 0.93 -3.81 (-16.65, 9.03)2 0.55 -5.04 (-19.41, 9.33)2 0.48
Change in BMI -14.88 (-35.01, 5.26)1 0.15 -16.44 (-35.66, 2.78)3 0.09 -17.75 (-39.41, 3.91)3 0.10
Tibiofemoral cartilage defects (yes/no)
Current BMI 1.08 (1.02, 1.15)4 0.01 1.06 (1.00, 1.13)5 0.050 1.07 (1.00, 1.14)5 0.050
Baseline BMI 1.09 (1.01, 1.18)4 0.02 1.06 (0.98, 1.15)5 0.13 1.05 (0.97, 1.14)5 0.25
Change in BMI 1.08 (0.97, 1.20)4 0.15 1.08 (0.96, 1.21)6 0.20 1.13 (1.00, 1.29)6 0.060
Bone marrow lesions (yes/no)
Current BMI 1.13 (1.04, 1.23)7 0.005 1.13 (1.04, 1.23)8 0.005 1.14 (1.03, 1.27)8 0.01
Baseline BMI 1.14 (1.03, 1.26)7 0.009 1.14 (1.03, 1.26)8 0.009 1.17 (1.02, 1.33)8 0.02
Change in BMI 1.15 (0.96, 1.38)7 0.14 1.14 (1.03, 1.26)9 0.01 1.12 (0.88, 1.43)9 0.36
  1. Total population of n = 142a, and subgroup analysis of those without osteophytes, n = 129b.
  2. BMI, body mass index.
  3. 1 Difference in cartilage volume per unit increase in BMI.
  4. 2 Difference in cartilage volume per unit increase in BMI adjusted for age, tibial plateau area.
  5. 3 Difference in cartilage volume per unit increase in BMI adjusted for age, tibial plateau area, and baseline BMI.
  6. 4 Odds of tibiofemoral cartilage defects per unit increase in BMI.
  7. 5 Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age, tibial plateau area.
  8. 6 Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age, tibial plateau area, and baseline BMI.
  9. 7 Odds of bone marrow lesions per unit increase in BMI.
  10. 8 Odds of bone marrow lesions unit increase in BMI adjusted for age.
  11. 9 Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age and baseline BMI.