Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?

Table 2 Relationship between BMI (kg/m²), and cartilage properties and bone marrow lesions in the tibiofemoral compartment

	Univariate analysis n = 142	P value	Multivariate analysis^an = 142	P value	Multivariate analysis^bn = 129	P value
Cartilage volume (ml)
Current BMI	-4.20 (-14.58, 6.18)¹	0.42	-6.98 (-16.98, 3.02)²	0.17	-7.73 (-18.55, 3.09)²	0.16
Baseline BMI	-0.60 (-13.51, 12.32)¹	0.93	-3.81 (-16.65, 9.03)²	0.55	-5.04 (-19.41, 9.33)²	0.48
Change in BMI	-14.88 (-35.01, 5.26)¹	0.15	-16.44 (-35.66, 2.78)³	0.09	-17.75 (-39.41, 3.91)³	0.10
Tibiofemoral cartilage defects (yes/no)
Current BMI	1.08 (1.02, 1.15)⁴	0.01	1.06 (1.00, 1.13)⁵	0.050	1.07 (1.00, 1.14)⁵	0.050
Baseline BMI	1.09 (1.01, 1.18)⁴	0.02	1.06 (0.98, 1.15)⁵	0.13	1.05 (0.97, 1.14)⁵	0.25
Change in BMI	1.08 (0.97, 1.20)⁴	0.15	1.08 (0.96, 1.21)⁶	0.20	1.13 (1.00, 1.29)⁶	0.060
Bone marrow lesions (yes/no)
Current BMI	1.13 (1.04, 1.23)⁷	0.005	1.13 (1.04, 1.23)⁸	0.005	1.14 (1.03, 1.27)⁸	0.01
Baseline BMI	1.14 (1.03, 1.26)⁷	0.009	1.14 (1.03, 1.26)⁸	0.009	1.17 (1.02, 1.33)⁸	0.02
Change in BMI	1.15 (0.96, 1.38)⁷	0.14	1.14 (1.03, 1.26)⁹	0.01	1.12 (0.88, 1.43)⁹	0.36

Total population of n = 142^a, and subgroup analysis of those without osteophytes, n = 129^b.
BMI, body mass index.
¹ Difference in cartilage volume per unit increase in BMI.
² Difference in cartilage volume per unit increase in BMI adjusted for age, tibial plateau area.
³ Difference in cartilage volume per unit increase in BMI adjusted for age, tibial plateau area, and baseline BMI.
⁴ Odds of tibiofemoral cartilage defects per unit increase in BMI.
⁵ Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age, tibial plateau area.
⁶ Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age, tibial plateau area, and baseline BMI.
⁷ Odds of bone marrow lesions per unit increase in BMI.
⁸ Odds of bone marrow lesions unit increase in BMI adjusted for age.
⁹ Odds of tibiofemoral cartilage defects per unit increase in BMI adjusted for age and baseline BMI.

ISSN: 1478-6362