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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis

Figure 1

Pain-related behaviour in the different treatment groups. (a) Thresholds indicating primary mechanical hyperalgesia are significantly reduced in saline i.a.-treated animals in the acute phase of arthritis, i.a.-sgp130-treated animals show a significantly faster recovery with increased thresholds on Days 3 and 7 after induction of arthritis. (b) i.p.-sgp130-treated animals show a faster increase of thresholds as compared to i.p.-saline-treated animals in the chronic phase of AIA (Days 14 and 21). (c) Overall antinociceptive effects as calculated from areas under the curve. Data are presented as mean ± SEM. *P < 0.05; **P < 0.01; n = 9 for all groups. Controls in (A) and (B) show values from immunized rats without AIA induction.

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