Locomotor behaviour in the different treatment groups as assessed from paw print analysis. (a) Left-right (LR) distances in i.a.-treated animals (for explanation of the parameter, see (c)), showing an attenuation of pain-related gait changes. (b) Left-right distances in i.p.-treated animals, showing no differences between groups. (d), (e) Angles between paws (for explanation, see (c)) in i.a.- (d) and i.p.- (e) treated animals, again showing a beneficial effect of i.a. sgp130 treatment. (c), (f) Representative specimens of paw prints from a non-inflamed (c) and a saline- or sgp130 i.a.-treated animal, respectively (f). Arrows at the right side indicate the direction of walking, LR Left-right distance, RL Right-left distance. Data in A, B, D and E are presented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; n = 9 for all groups. Controls in (a), (b), (d), and (e) show values from immunized rats without AIA induction.