Inflammatory changes in the different treatment groups. Joint swelling in i.a.- (a) and i.p.- (b) treated AIA animals as compared to non-inflamed controls. (c) Anti-inflammatory effects as calculated from areas under the curve. Histopathological scores for inflammation (d) and cartilage and bone destruction (e) at day 21 of AIA, showing a beneficial effect for i.a.-sgp130-treated animals in the latter. Data are presented as mean ± SEM. *P < 0.05; n = 9 for all groups.