Table 1 Measures of secondary hyperalgesia and weight bearing
Treatment | Baseline | Day 1 | Day 3 | Day 7 | Day 14 | Day 21 |
|---|---|---|---|---|---|---|
Weight bearing [% on inflamed hindlimb] | ||||||
Saline i.p. | 49.7 ± 0.7 | 23.5 ± 3.1 | 27.0 ± 1.1 | 31.6 ± 2.4 | 40.0 ± 2.6 | 50.3 ± 2.1 |
Sgp130 i.p. | 49.8 ± 0.6 | 27.0 ± 2.6 | 25.3 ± 2.5 | 26.1 ± 3.3 | 40.8 ± 2.5 | 46.4 ± 1.7 |
Saline i.a. | 51.1 ± 0.6 | 30.6 ± 3.8 | 30.3 ± 1.5 | 33.6 ± 2.8 | 39.2 ± 2.4 | 45.5 ± 1.0 |
Sgp130 i.a. | 50.6 ± 0.8 | 32.4 ± 0.8 * | 38.0 ± 1.7+,** | 43.2 ± 1.3 +,** | 44.2 ± 1.2 | 48.4 ± 2.5 |
Mechanical thresholds paw [g] | ||||||
Saline i.p. | 26.2 ± 2.9 | 16.6 ± 1.7 | 12.5 ± 1.5 | 12.2 ± 1.3 | 12.3 ± 1.0 | 14.6 ± 1.9 |
Sgp130 i.p. | 24.6 ± 3.0 | 14.2 ± 2.4 | 16.7 ± 1.9 | 14.0 ± 1.1 | 12.3 ± 1.8 | 13.3 ± 1.7 |
Saline i.a. | 22.9 ± 2.1 | 14.5 ± 3.7 | 12.8 ± 1.8 | 9.8 ± 2.6 | 9.0 ± 2.4 | 12.3 ± 2.4 |
sgp130 i.a. | 24.4 ± 1.6 | 15.5 ± 2.0 | 14.5 ± 2.2 | 12.7 ± 1.8 | 15.1 ± 2.6 | 14.7 ± 2.1 |
Thermal withdrawal thresholds paw [s] | ||||||
Saline i.p. | 15.3 ± 0.8 | 10.3 ± 0.9 | 10.3 ± 0.9 | 8.7 ± 0.8 | 8.4 ± 0.9 | 9.3 ± 0.9 |
sgp130 i.p. | 14.9 ± 0.7 | 10.2 ± 0.8 | 11.3 ± 1.4 | 8.2 ± 1.3 | 9.4 ± 1.0 | 10.2 ± 0.9 |
Saline i.a. | 14.9 ± 0.6 | 9.8 ± 0.8 | 9.5 ± 0.8 | 9.3 ± 1.1 | 10.1 ± 0.9 | 10.3 ± 1.3 |
sgp130 i.a. | 13.4 ± 0.7 | 9.4 ± 0.7 | 10.7 ± 0.8 | 10.0 ± 0.7 | 10.5 ± 1.2 | 12.4 ± 1.0 |