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Table 1 Measures of secondary hyperalgesia and weight bearing

From: Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis

Treatment Baseline Day 1 Day 3 Day 7 Day 14 Day 21
Weight bearing [% on inflamed hindlimb]
Saline i.p. 49.7 ± 0.7 23.5 ± 3.1 27.0 ± 1.1 31.6 ± 2.4 40.0 ± 2.6 50.3 ± 2.1
Sgp130 i.p. 49.8 ± 0.6 27.0 ± 2.6 25.3 ± 2.5 26.1 ± 3.3 40.8 ± 2.5 46.4 ± 1.7
Saline i.a. 51.1 ± 0.6 30.6 ± 3.8 30.3 ± 1.5 33.6 ± 2.8 39.2 ± 2.4 45.5 ± 1.0
Sgp130 i.a. 50.6 ± 0.8 32.4 ± 0.8 * 38.0 ± 1.7+,** 43.2 ± 1.3 +,** 44.2 ± 1.2 48.4 ± 2.5
Mechanical thresholds paw [g]
Saline i.p. 26.2 ± 2.9 16.6 ± 1.7 12.5 ± 1.5 12.2 ± 1.3 12.3 ± 1.0 14.6 ± 1.9
Sgp130 i.p. 24.6 ± 3.0 14.2 ± 2.4 16.7 ± 1.9 14.0 ± 1.1 12.3 ± 1.8 13.3 ± 1.7
Saline i.a. 22.9 ± 2.1 14.5 ± 3.7 12.8 ± 1.8 9.8 ± 2.6 9.0 ± 2.4 12.3 ± 2.4
sgp130 i.a. 24.4 ± 1.6 15.5 ± 2.0 14.5 ± 2.2 12.7 ± 1.8 15.1 ± 2.6 14.7 ± 2.1
Thermal withdrawal thresholds paw [s]
Saline i.p. 15.3 ± 0.8 10.3 ± 0.9 10.3 ± 0.9 8.7 ± 0.8 8.4 ± 0.9 9.3 ± 0.9
sgp130 i.p. 14.9 ± 0.7 10.2 ± 0.8 11.3 ± 1.4 8.2 ± 1.3 9.4 ± 1.0 10.2 ± 0.9
Saline i.a. 14.9 ± 0.6 9.8 ± 0.8 9.5 ± 0.8 9.3 ± 1.1 10.1 ± 0.9 10.3 ± 1.3
sgp130 i.a. 13.4 ± 0.7 9.4 ± 0.7 10.7 ± 0.8 10.0 ± 0.7 10.5 ± 1.2 12.4 ± 1.0
  1. Sgp, soluble glycoprotein 130; i.a., intra-articular; i.p., intra-peritoneal; data are presented as mean ± SEM. * differences between sgp130 i.p. and and sgp130 i.a.; + differences between sgp130 i.a. and saline i.a.; one symbol P < 0.05; two symbols P < 0.01.