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Table 2 Effect of BCP and CPPD on macrophage DNA synthesis

From: Inflammatory microcrystals induce murine macrophage survival and DNA synthesis


[3H]TdR incorporation (cpm × 10-4)


  1.3 ± 0.1


25.2 ± 0.6


   3.1 ± 0.1a

  1. BMMs from which CSF-1 had just been removed were cultured as described in Table 1. After one day, cells were washed twice to remove cystals and recultured in RPMI/10% FBS containing [3H]TdR (2 μCi) for a further two days. Data are mean values ± SEMfrom triplicate cultures and are from a representative experiment that was repeated eight times. aP < 0.05 in comparison with untreated group (Student's two-tailed t-test).