TY - JOUR AU - Davignon, Jean-Luc AU - Boyer, Jean-Frédéric AU - Jamard, Bénédicte AU - Nigon, Delphine AU - Constantin, Arnaud AU - Cantagrel, Alain PY - 2010 DA - 2010/07/15 TI - Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments JO - Arthritis Research & Therapy SP - R142 VL - 12 IS - 4 AB - Anti-tumor necrosis factor (TNF)-α biotherapies have considerably changed the treatment of rheumatoid arthritis (RA). However, serious infections are a major concern in patients with rheumatic diseases treated with anti-TNF-α. Little is known about viral, especially latent, infections in anti-TNF-α treatments. Infections by cytomegalovirus (CMV), a β-herpes virus, are frequent and induce a strong CD4pos T-cell immunity, which participates in the control of infection. We thus have chosen to analyze the CD4pos T-cell response to CMV antigens as a model of antiviral response in RA patients treated with anti-TNF-α. CD28 expression was evaluated. SN - 1478-6354 UR - https://doi.org/10.1186/ar3083 DO - 10.1186/ar3083 ID - Davignon2010 ER -