TY - JOUR AU - Lems, Willem F. AU - den Uyl, Debby PY - 2010 DA - 2010/07/29 TI - Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives? JO - Arthritis Research & Therapy SP - 131 VL - 12 IS - 4 AB - Osteoarthritis (OA) of the knee is a common chronic disease leading to increased morbidity and reduced quality of life. Although exercise therapy has been shown to be beneficial for both pain and physical functioning, its underlying mechanism is not fully understood. However, a recent study found an exercise-induced increase in interleukin-10 levels, to which anti-inflammatory and chondroprotective properties are ascribed, in the (peri-)synovial fluid of patients with knee OA. These interesting results provide more insight into the effects of exercise in OA and need to be validated and confirmed. Hopefully, the study offers a promising basis for further research SN - 1478-6354 UR - https://doi.org/10.1186/ar3084 DO - 10.1186/ar3084 ID - Lems2010 ER -