Skip to main content

Table 2 Distribution of the histological liver lesions depending on the associated rheumatic disease

From: Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes

  AIH-like lesions NASH-like lesions Limited liver lesions PBC Direct MTX toxicity Total
Rheumatoid arthritis 13 (31.7%) 9 (22%) 1 (2.4%) 1 (2.4%) 1 (2.4%) 25 (61%)
Spondylarthropathy 2 (4.9%) 3 (7.3%) 2 (4.9%) 0 (0%) 1 (2.4%) 8 (19.5%)
Primary Sjögren syndrome 0 (0%) 1 (2.4%) 4 (9.8%) 1 (2.4%) 0 (0%) 6 (14.6%)
Connective tissue disease 2 (4.9%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 2 (4.9%)
  17 (41.5%) 13 (31.7%) 7 (17%) 2 (4.9%) 2 (4.9%) 41 (100%)
  1. Data presented as n (%). AIH, autoimmune hepatitis; MTX, methotrexate; NASH, nonalcoholic steatohepatitis; PBC, primary biliary cirrhosis.