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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

Figure 3

Diagrams of the patterns of association observed between SNP genotype, serologic profile, and serum IFN-α. "Gene" represents the genetic variation in the locus studied, and "Ab" represents the particular serologic profile associated with that locus. Connecting lines between nodes indicate associations, and arrowheads show the hypothesized direction of the relationship. The loci demonstrating each pattern are indicated following the letter labeling the panel. The dashed line in C. indicates that a suggestive association was seen between the EFNA5 SNP genotype and the same serologic profile which is linked to IFN-α, but this serologic association did not withstand Bonferroni correction for multiple comparisons.

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