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Table 1 Serologic associations observed in SLE patients in the replication cohort, best fit model from logistic regression

From: Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus

Locus and Allele Associated Antibody Profile Ancestral Background Odds Ratio (95% CI) P-value
LRRC20 rs10762360 G Anti-La AA 2.40
(1.51 to 3.81)
1.6 × 10-4
PPM1 H rs10784318 C Anti-La EA and HA joint 3.74
(1.88 to 7.47)
3.6 × 10-5
LPAR1 rs10980684 T Anti-Ro with Anti-Sm AA and HA joint 2.22
(1.42 to 3.47)
1.2 × 10-4
ANKS1A rs2820223 C Anti-Ro with Anti-dsDNA AA 3.14
(1.68 to 5.87)
3.5 × 10-4
PTPRM rs17494870 C - - - -
EFNA5 rs26725 C Anti-RNP AA 1.73
(1.10 to 2.72)
0.018
VSIG2 rs11219769 T Anti-RNP lacking Anti-Sm EA and HA joint 3.99
(1.81 to 8.75)
2.1 × 10-4
  1. AA, African-American, EA, European-American, HA, Hispanic-American, 95% CI, 95% confidence interval; "joint" indicates that two or more ancestral backgrounds showed a similar tendency when analyzed separately with a non-significant difference observed between odds ratios, and that the indicated ancestral backgrounds were analyzed jointly using a fixed-effects model.