Experimental design. This study evaluated the effect of increased remodelling on subchondral bone microstructure and biomechanical-related genometrics in a combined rabbit model of osteoarthritis (OA) aggravated by previous osteoporosis (OP). (a)Experimental scheme. OVX: ovariectomy; MPH: methylprednisolone hemysuccinate. (b)Qualitative 2D models were reconstructed from images selected of a highly representative sample for each group (HEALTHY, OA, OP and OPOA), by using the CTAn software (Skyscan, Aartselaar, Belgium).