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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain

Figure 3

In vitro depletion of B22a1+ T cells reduces recall response to collagen type II. Vβ12-transgenic mice were immunized with collagen type II (CII) and 10 days later lymph node cells were depleted of B22a1+ T cells in vitro, and alterations in the CII-specific [H3]thymidine incorporation were noted after 4 days of culture with lathyritic CII, K264 peptide, GalHyK264 peptide, medium alone and ConA. Data show mean ± standard error of the mean of four individual mice before and after depletion. *P < 0.05. CPM, counts per minute.

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Arthritis Research & Therapy

ISSN: 1478-6362

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