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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain

Figure 4

Collagen type II-specific T cells expand in priming phase and retract when arthritis symptoms appear. The indicated numbers of Vβ12-transgenic mice were immunized with collagen type II (CII) and were followed for development of arthritis (stars, referring to right y axis). In parallel, frequencies of B22a1+ T cells in CII-primed Vβ12-transgenic mice and wildtype (WT) littermates were assessed by flow cytometry in draining lymph nodes (LNs, open squares and closed circles), spleen (open and closed triangles) and mesenteric lymph node (mLN, open circles and closed diamonds) (referring to left y axis). Data show the mean ± standard error of the mean of four individual mice (WT littermates), five individual mice (Vβ12-transgenic) and 14 individual mice (day 35).

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Arthritis Research & Therapy

ISSN: 1478-6362

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