Figure 2
From: Bone events and evolution of biologic markers in Gaucher disease before and during treatment
Biomarker changes under enzyme-replacement therapy (ERT): impact of covariates. (a) platelet level, (b) chitotriosidase, (c) ferritin, (d) angiotensin-converting enzyme (ACE), and (e) tartrate-resistant acid phosphatase (TRAP). Different covariates were tested to identify those impacting on biomarker evolution (baseline or variation slope): splenectomy, diagnosis year (before 1991 or after 1991, the year ERT became available), genotype (N370S/N370S or others), age at diagnosis (before 15 or after 15 years old) and sex. Solid grey horizontal lines correspond to the normal biomarker value: platelet level >150,000/mm3; chitotriosidase <100 nmol/mL/h; ferritin <250 ng/L; ACE <45 IU/L; TRAP <7 IU/L. When a covariate had a significant impact on the baseline value or the variation slope, the different curves are shown.