From: Bone events and evolution of biologic markers in Gaucher disease before and during treatment
Slope of variation (Unit) | P a | ||||||
---|---|---|---|---|---|---|---|
Biomarker | No./no. | Before ERT | No./no. | During ERT | No./no. | Full-dose ERT | |
Platelets (no splenectomy)b | 9/70 | 190/mm3/y | 38/480 | 7,035/mm3/y | 33/220 | 10,231/mm3/y | <0.0001 |
Chitotriosidase | 10/23 | -11%/y | 52/226 | -17%/y | 37/134 | -14%/y | 0.14 |
TRAP | 7/14 | -0.7%/y | 36/214 | -4%/y | 24/109 | -6%/y | 0.78 |
ACE | 9/33 | 0.1%/y | 46/263 | -5%/y | 31/114 | -4%/y | 0.88 |
Ferritin | 9/45 | 4%/y | 47/338 | -14%/y | 37/166 | -16%/y | <0.0001 |