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Table 2 Frequencies of GR polymorphisms in RA patients vs. controls from the Rotterdam study, adjusted for age and sex

From: Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis

Polymorphism

RA

Case, n (%)

Rotterdam study

Control, n (%)

Unadjusted

OR (95% CI)

P-value

Adjusted

OR (95% CI)

P-value

ER22/23EK

      

   Non-carriers

336 (91.3%)

4721 (93.8%)

reference

 

reference

 

   Carriers

32 (8.7%)1

312 (6.2%)2

1.44 (0.99-2.10)

0.058

1.42 (0.95-2.13)

0.086

N363S

      

   Non-carriers

352 (95.7%)

4664 (92.7%)

reference

 

reference

 

   Carriers

16 (4.3%)

369 (7.4%)3

0.58 (0.35-0.95)

0.032

0.55 (0.32-0.96)

0.034

BclI

      

   Non-carriers

176 (47.8%)

1979 (39.3%)

reference

 

reference

 

   Carriers*

192 (52.2%)

3054 (60.7%)

0.71 (0.57-0.87)

0.001

0.73 (0.58-0.91)

0.006

   Heterozygous carriers

149 (40.5%)

2370 (47.1%)

0.71 (0.56-0.89)

0.003

0.72 (0.57-0.92)

0.008

   Homozygous carriers

43 (11.7%)

684 (13.6%)

0.71 (0.50-0.996)

0.047

0.74 (0.52-1.07)

0.108

      

   Non-carriers

233 (63.3%)

3445 (68.4%)

reference

 

reference

 

   Carriers*

135 (36.7%)

1588 (31.6%)

1.26 (1.01-1.57)

0.041

1.26 (1.00-1.60)

0.050

   Heterozygous carriers

124 (33.7%)

1437 (28.6%)

1.28 (1.02-1.60)

0.035

1.13 (1.004-1.62)

0.047

   Homozygous carriers

11 (3.0%)

151 (3.0%)

1.08 (0.58-2.00)

0.816

1.08 (0.58-2.22)

0.720

  1. 1 One homozygous carrier.
  2. 2 Eight homozygous carriers.
  3. 3 Four homozygous carriers.
  4. * This includes hetero- and homozygous carriers.
  5. CI, confidence interval; GR, glucocorticoid receptor; OR, odds ratio; RA, rheumatoid arthritis.