Table 3 Frequencies of GR polymorphisms in RA patients vs. blood donor controls, adjusted for age and sex
Polymorphism | RA Case, n (%) | Blood donors Control, n (%) | Unadjusted OR (95% CI) | P-value | Adjusted OR (95% CI) | P-value |
|---|---|---|---|---|---|---|
ER22/23EK | ||||||
Non-carriers | 336 (91.3%) | 495 (93.0%) | reference | reference | ||
Carriers | 32 (8.7%)1 | 37 (7.0%)2 | 1.27 (0.78-2.08) | 0.335 | 1.54 (0.82-2.90) | 0.181 |
N363S | ||||||
Non-carriers | 352 (95.7%) | 493 (92.7%) | reference | reference | ||
Carriers | 16 (4.3%) | 39 (7.3%) | 0.58 (0.32-1.04) | 0.066 | 0.71 (0.34-1.50) | 0.380 |
BclI | ||||||
Non-carriers | 176 (47.8%) | 199 (37.4%) | reference | reference | ||
Carriers* | 192 (52.2%) | 333 (62.6%) | 0.65 (0.50-0.85) | 0.002 | 0.61 (0.43-0.86) | 0.005 |
Heterozygous carriers | 149 (40.5%) | 255 (47.9%) | 0.66 (0.50-0.88) | 0.004 | 0.63 (0.44-0.92) | 0.015 |
Homozygous carriers | 43 (11.7%) | 78 (14.7%) | 0.62 (0.41-0.95) | 0.028 | 0.53 (0.31-0.92) | 0.024 |
9β | ||||||
Non-carriers | 233 (63.3%) | 367 (69.0%) | reference | reference | ||
Carriers* | 135 (36.7%) | 165 (31.0%) | 1.29 (0.97-1.71) | 0.076 | 1.44 (1.001-2.07) | 0.049 |
Heterozygous carriers | 124 (33.7%) | 147 (27.6%) | 1.33 (0.995-1.78) | 0.054 | 1.52 (1.05-2.22) | 0.028 |
Homozygous carriers | 11 (3.0%) | 18 (3.4%) | 0.96 (0.45-2.04) | 0.992 | 0.85 (0.32-2.27) | 0.746 |