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Table 1 Overview of pooled clinical data from two individual experiments

From: A multiparameter approach to monitor disease activity in collagen-induced arthritis

  

Incidence of arthritis

Day of onset of arthritis

Day 42 score

Treatment groups

N

Frequency of arthritis (%)

P- value (Fisher's exact test)

Median

IQR

P- value (MW) (compared to PBS)

Median

IQR

P- value (MW) (compared to PBS)

Vehicle (PBS)

24

87.5

 

29

26 to 33

 

3.25

3 to 6

 

Dexamethasone

23

4.3

0.000*

ND

ND

ND

0

0 to 0

0.000*

Etanercept

23

69.6

0.168*

33

23 to 35

0.600

0.5

0 to 3.5

0.004*

Zoledronic acid

24

83.3

1.000*

31

28 to 32

0.212

4.5

0.625 to 6

0.840*

Abatacept

23

73.9

0.286*

28

25 to 32

0.400

3

0 to 7

0.378*

  1. Depicted are the number of mice (N), frequency of arthritis at Day 42, median day of onset and median arthritis score at Day 42 with their interquartile range (IQR) and P-values (*: significant P-values according to Mann-Whitney U test (MW) and correction using the Holm procedure). Fisher's exact test for frequencies of arthritis: P < 0.001; Kruskall Wallis test for day of onset: P = 0.349; Kruskall Wallis test for Day 42 score: P < 0.001. ND, not determined. PBS, phosphate buffered saline.
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Arthritis Research & Therapy

ISSN: 1478-6362

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