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Table 1 Overview of pooled clinical data from two individual experiments

From: A multiparameter approach to monitor disease activity in collagen-induced arthritis

   Incidence of arthritis Day of onset of arthritis Day 42 score
Treatment groups N Frequency of arthritis (%) P- value (Fisher's exact test) Median IQR P- value (MW) (compared to PBS) Median IQR P- value (MW) (compared to PBS)
Vehicle (PBS) 24 87.5   29 26 to 33   3.25 3 to 6  
Dexamethasone 23 4.3 0.000* ND ND ND 0 0 to 0 0.000*
Etanercept 23 69.6 0.168* 33 23 to 35 0.600 0.5 0 to 3.5 0.004*
Zoledronic acid 24 83.3 1.000* 31 28 to 32 0.212 4.5 0.625 to 6 0.840*
Abatacept 23 73.9 0.286* 28 25 to 32 0.400 3 0 to 7 0.378*
  1. Depicted are the number of mice (N), frequency of arthritis at Day 42, median day of onset and median arthritis score at Day 42 with their interquartile range (IQR) and P-values (*: significant P-values according to Mann-Whitney U test (MW) and correction using the Holm procedure). Fisher's exact test for frequencies of arthritis: P < 0.001; Kruskall Wallis test for day of onset: P = 0.349; Kruskall Wallis test for Day 42 score: P < 0.001. ND, not determined. PBS, phosphate buffered saline.