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Table 3 Best-fit models for clinical score, and cartilage and bone destruction predicted by different serum markers

From: A multiparameter approach to monitor disease activity in collagen-induced arthritis

Dependent variable Best-fit model Adjusted R2 Significance
Clinical score MMP-3 0.414 < 0.001
  MMP-3 + anti-collagen IgG2a 0.499 < 0.001
Cartilage destruction MMP-3 0.451 < 0.001
  MMP-3 + CTXII 0.485 < 0.001
Bone destruction MMP-3 0.372 < 0.001
  MMP-3 + anti-collagen IgG2a 0.411 < 0.001
  1. Best-fit models for clinical score, and cartilage and bone destruction in the knee joint as proposed by linear regression analysis with nine serum markers and treatment group as independent variables. MMP-3, matrix metalloproteinase-3.