Figure 5
From: The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
COX-2 and b-ALP gene expression in treated bone stromal cells. (a) COX-2 gene expression of bone marrow stromal cells treated with risedronate (Ris) at different concentrations (0.1 to 10 μM) in presence or absence of NS-398 COX-2 inhibitor. Note that Ris induces significant COX-2 expression in a dose dependent manner. (b) COX-2 gene expression of bone marrow stromal cells treated with risedronate (Ris) at different concentrations (0.1 to 10 μM) in presence of dexametasone 1 μM (DEX). (c) bALP gene expression of bone marrow stromal cells treated with risedronate (Ris) at different concentrations in presence or absence of NS-398 COX-2 inhibitor. The experiments were performed in triplicate.