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Table 1 Histomorphometric results in rats treated with glucocorticoids (GC) and risedronate (Ris)

From: The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation

  Controls Ris GC GC+Ris
Bone volume/tissue volume (%) 35 ± 1 39 ± 1(b,c) 31 ± 1(b) 36 ± 1(a)
Trabecular thickness (μm) 50 ± 1 55 ± 1(b) 43 ± 1(b) 53 ± 1(a)
Trabecular number (N/mm) 3.4 ± 0.2 4.6 ± 0.1(b) 2.9 ± 0.1(b) 4.4 ± 0.1(a,b)
Trabecular separation (μm) 155 ± 6.5 139 ± 4.8(b,c) 273 ± 5.3(b) 144 ± 6.1(a)
Mineral apposition rate (μm/day) 0.66 ± 0.04 0.65 ± 0.04 0.62 ± 0.05(b) 0.65 ± 0.04
Mineralized surface/BS (%) 11.2 ± 1.5 9.8 ± 0.9(b) 9.6 ± 0.9(b) 9.8 ± 1.0(b)
Bone formation rate/BS (μm3/μm2/day 7.4 ± 1.2 6.3 ± 0.6(b) 5.9 ± 0.6(b) 6.3 ± 0.6(b)
Wall thickness (μm) 16.8 ± 1.3 24.9 ± 3.6(b) 12.0 ± 3.1(b) 22.8 ± 5.9(a,b)
Activation frequency (N/yr) 1.6 ± 0.3 0.9 ± 0.2(b) 1.9 ± 0.6 1.0 ± 0.3(a,b)
Active formation period (days) 25.4 ± 2.0 38.8 ± 5.4(b) 19.4 ± 4.8 35.3 ± 9.3(a,b)
Eroded surface/BS (%) 1.9 ± 1.0 1.7 ± 0.7 2.2 ± 1.1 1.9 ± 1.1
  1. BS, bone surface.
  2. a) P < 0.001 vs GC. b) P < 0.05/P < 0.001 vs controls. c) P < 0.001 vs GC + Ris.
  3. All values are expressed as mean ± SD.