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Table 1 Clinical characteristics of study participants

From: Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion

 

All PsA

n= 38

Erosive PsA

n= 29

Nonerosive PsA

n= 9

Psoriasis alone

n= 10

Healthy control

n= 12

Female sex, n (%)

16 (42%)

11 (38%)

5 (56%)

4 (40%)

11 (92%)b

Age, years, median (range)

50 (26-68)

50 (26-63)

47 (33-68)

44 (19-72)

48 (21-53)

Caucasian ethnicity, n (%)

32 (84%)

25 (86%)

7 (78%)

7 (70%)

10 (83%)

Weight, kg, median (range)

78 (32-116)

80 (65-114)

74 (32-116)

82 (67.9-103)

81 (46-109)

Psoriasis disease duration, years, median (range)

20 (0.5-50)

20 (3-50)

20 (0.5-40)

18 (0.4-53)

NA

Arthritis disease duration, years, median (range)

10 (0.5-45)

11 (5-33)

5 (0.5-45)

NA

NA

PASI, median (range)

1.6 (0-12)

1.5 (0-12)

1.6 (1-3.4)

13 (6.3-23.2)b

NA

Nail score, median (range)

7 (0-47)

9 (0-47)

6 (0-25)

6 (0-25)

NA

Creatinine, μmol/L, median (range)

77 (23-249)

78 (23-249)

77 (42-89)

76 (39-100)

NA

C-reactive protein, mg/L, median (range)

6.5 (1-59)

7.2 (1-59)

5.8 (1-26)

2.6 (1-7.2)b

2.1 (1-15)b

DAS28-CRP, median (range)

3.9 (1.4-6.6)

4.2 (2.3-6.6)

2.7 (1.4-6.0)a

NA

NA

Methotrexate use, n (%)

22 (58%)

15 (52%)

7 (78%)

1 (10%)b

0 (0)b

Prednisone use, n (%)

7 (18%)

4 (14%)

3 (33%)

0 (0)

0 (0)

Nonsteroidal antiinflammatory drug use, n (%)

19 (50%)

16 (55%)

3 (33%)

0 (0)b

0 (0)b

Biologics use, n (%)

0 (0)

0 (0)

0 (0)

0 (0)

0 (0)

XR erosion score, median (range)

29 (0-183)

43 (1-183)

0 (0-0)a

NA

NA

XR narrowing score, median (range)

24.5 (0-160)

36 (2-160)

0 (0-10)a

NA

NA

Combined XR score, median (range)

59 (0-343)

78 (3-343)

0 (0-10)a

NA

NA

Number of joints with pencil-in-cup deformities on XR, median (range)

0 (0-17)

0 (0-17)

0 (0-0)

NA

NA

Number of joints with new bone formation on XR, median (range)

1 (0-9)

1 (0-9)

0 (0-7)

NA

NA

Radiographic sacroiliitis, n (%)

15 (39%)

12 (41%)

3 (33%)

NA

NA

Total hip BMD T score, median (range)

-0.1 (-3.5-2.0)

-0.1 (-2.1-2.0)

-0.2 (-3.5-0.9)

NA

NA

  1. aP < 0.05, compared with erosive PsA; bP < 0.05, compared with all PsA. BMD, bone mineral density DAS, disease activity score; PASI, Psoriasis Area and Severity Index; XR, x-ray. NA, not assessed.