Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion

Table 2 Stromal cell-derived mediators of bone remodeling and bone pathology scores in patients with PsA

	Median (range)	XR erosion score	XR narrowing score	Combined XR score	Number of joints with pencil-in-cup deformities on XR	Number of joints with new bone formation on XR	Total hip BMD Tscore
Dkk-1	2,977 (1,163-5,908) pg/ml	0.15	0.10	0.15	-0.12	0.22	-0.13
M-CSF	408 (120-1,166) pg/ml	0.53^b	0.54^b	0.52^b	0.36^a	0.09	-0.06
OPG	1,871 (179.5-7,367) pg/ml	-0.13	-0.03	-0.08	0.09	-0.12	-0.10
RANKL	0.031 (0-0.49) pmol/L	0.36^a	0.35^a	0.36^a	0.41^a	0.08	-0.03

^aP < 0.05; ^bP < 0.01. Spearman r values for correlations between circulating concentrations of stromal cell-derived mediators of bone remodeling and measures of bone pathology. BMD, bone mineral density; Dkk-1, Dikkopf-1; M-CSF, macrophage-colony stimulating factor; OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor-κB ligand; XR, x-ray.

ISSN: 1478-6362