Figure 1

Expression of HMGB1 protein in human synovium. (a) Representative immunohistochemical sections of normal (n = 3) and osteoarthritic (n = 3) human synovium with high mobility group box 1 (HMGB1) revealed in 3,3'-diaminobenzidine (DAB). Arrows indicate HMGB1 positive cells. Original magnification × 100. (b) Histograms of normal and osteoarthritic positive cells (%) in the synovial lining cell nucleus and cytoplasm and vicinity. Data are expressed as mean ± standard error of the mean (n = 3). *P < 0.05 with respect to normal.