Table 3 Predictive significance of Severity Index subscales for progression of FVC
Medsger Severity Index | Main effect adjusted for follow-up time | Interaction term of baseline FVC within 3 years of follow-up | Interaction term between baseline FVC and up to 11 years of follow-up | |||
|---|---|---|---|---|---|---|
| Â | b(95% CI) | Pvalue | b(95% CI) | Pvalue | b(95% CI) | Pvalue |
General | -0.22 (-3.65 to 3.19) | 0.897 | 0.0 (-0.01 to 0.01) | 0.463 | 0.01 (-0.48 to 0.5) | 0.972 |
Peripheral vascular | -0.81 (-3.31 to 1.69) | 0.525 | 0.0 (-0.01 to 0.01) | 0.436 | 0.1 (-0.21 to 0.41) | 0.513 |
Skin | -3.61 (-7 to -0.22) | 0.037 | 0.58 (-2.41 to 1.24) | 0.531 | 0.17 (-0.27 to 0.61) | 0.449 |
Joint/tendon | -2.14 (-4.48 to 0.19) | 0.072 | -0.19 (-1.15 to 0.75) | 0.682 | -0.06 (-0.37 to 0.25) | 0.712 |
Muscle | -5.61 (-12.22 to 1) | 0.096 | -0.32 (-1.27 to 0.63) | 0.504 | 0.23 (-0.61 to 1.07) | 0.588 |
Gastrointestinal tract | -0.26 (-4.58 to 4.06) | 0.905 | 0.0 (-0.01 to 0.01) | 0.369 | 0.02 (-0.61 to 0.65) | 0.955 |
Lung | -9.73 (-11.91 to -7.55) | < 0.001 | 0.0 (-0.01 to 0.01) | 0.707 | -0.29 (-0.62 to 0.03) | 0.077 |
Heart | -1.98 (-6.17 to 2.2) | 0.353 | 0.0 (-0.01 to 0.01) | 0.321 | 0.24 (-0.44 to 0.92) | 0.493 |
Kidney | 0.62 (-6.84 to 8.09) | 0.87 | 0.0 (-0.01 to 0.01) | 0.128 | -0.22 (-1.64 to 1.19) | 0.756 |