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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy

Figure 2

Light micrographs (magnification, 100x) of ankle joint histology for the six animal groups. Synovial lining and villous hyperplasia, cellular infiltration in periarticular soft tissue, bone and cartilage destruction are clearly evident in the free dexamethasone (Dex), the N-(2-hydroxypropyl)methacrylamide polymer without Dex (PHPMA) and the saline groups. P-Dex, acid-labile N-(2-hydroxypropyl)methacrylamide copolymer-dexamethasone conjugate.

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