| |
Genotype
|
Allele
|
Allelic Association
|
Recessive Model*
|
|---|
| |
C/C
|
C/G
|
G/G
|
C
|
P
|
OR (95%CI)
|
P
|
OR (95%CI)
|
|---|
|
All RA (n = 553)
|
292 (52.8)
|
215 (38.9)
|
46 (8.3)
|
799 (72.2)
|
0.23
|
1.12 (0.93-1.35)
|
0.21
|
1.17 (0.92-1.49)
|
|
All healthy controls (n = 513)
|
251 (48.9)
|
215 (41.9)
|
47 (9.2)
|
717 (69.9)
| |
reference
| |
reference
|
|
HLA-DRB1 shared epitope positive
| | | | | | | |
|
RA (n = 376)
|
203 (54.0)
|
142 (38.7)
|
31 (8.2)
|
548 (72.9)
|
0.76
|
1.04 (0.80-1.37)
|
0.57
|
1.11 (0.78-1.56)
|
|
Healthy controls (n = 202)
|
104 (51.5)
|
83 (41.1)
|
15 (7.4)
|
291 (72.0)
| |
reference
| |
reference
|
|
HLA-DRB1 shared epitope negative
| | | | | | | |
|
RA (n = 171)
|
86 (50.3)
|
70 (40.9)
|
15 (8.8)
|
242 (70.8)
|
0.67
|
1.07 (0.80-1.43)
|
0.68
|
1.08 (0.74-1.58)
|
|
Healthy controls (n = 296)
|
143 (48.3)
|
125 (42.2)
|
28 (9.5)
|
411 (69.4)
| |
reference
| |
reference
|
- OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
- Association was tested by χ2 analysis using 2 × 2 contingency tables. Comparisons were made between all RA and all healthy controls, HLA-DRB1 shared epitope positive RA and controls, and shared epitope negative RA and controls.
- *Association was tested under the recessive model for rs7708392C allele.
