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Table 3 Association study of TNIP1 rs7708392 with RA in a Japanese population

From: Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

 

Genotype

Allele

Allelic Association

Recessive Model*

 

C/C

C/G

G/G

C

P

OR (95%CI)

P

OR (95%CI)

All RA (n = 553)

292 (52.8)

215 (38.9)

46 (8.3)

799 (72.2)

0.23

1.12 (0.93-1.35)

0.21

1.17 (0.92-1.49)

All healthy controls (n = 513)

251 (48.9)

215 (41.9)

47 (9.2)

717 (69.9)

 

reference

 

reference

HLA-DRB1 shared epitope positive

       

   RA (n = 376)

203 (54.0)

142 (38.7)

31 (8.2)

548 (72.9)

0.76

1.04 (0.80-1.37)

0.57

1.11 (0.78-1.56)

   Healthy controls (n = 202)

104 (51.5)

83 (41.1)

15 (7.4)

291 (72.0)

 

reference

 

reference

HLA-DRB1 shared epitope negative

       

   RA (n = 171)

86 (50.3)

70 (40.9)

15 (8.8)

242 (70.8)

0.67

1.07 (0.80-1.43)

0.68

1.08 (0.74-1.58)

   Healthy controls (n = 296)

143 (48.3)

125 (42.2)

28 (9.5)

411 (69.4)

 

reference

 

reference

  1. OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
  2. Association was tested by χ2 analysis using 2 × 2 contingency tables. Comparisons were made between all RA and all healthy controls, HLA-DRB1 shared epitope positive RA and controls, and shared epitope negative RA and controls.
  3. *Association was tested under the recessive model for rs7708392C allele.