Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

Table 3 Association study of TNIP1 rs7708392 with RA in a Japanese population

	Genotype			Allele	Allelic Association		Recessive Model*
	C/C	C/G	G/G	C	P	OR (95%CI)	P	OR (95%CI)
All RA (n = 553)	292 (52.8)	215 (38.9)	46 (8.3)	799 (72.2)	0.23	1.12 (0.93-1.35)	0.21	1.17 (0.92-1.49)
All healthy controls (n = 513)	251 (48.9)	215 (41.9)	47 (9.2)	717 (69.9)		reference		reference
HLA-DRB1 shared epitope positive
RA (n = 376)	203 (54.0)	142 (38.7)	31 (8.2)	548 (72.9)	0.76	1.04 (0.80-1.37)	0.57	1.11 (0.78-1.56)
Healthy controls (n = 202)	104 (51.5)	83 (41.1)	15 (7.4)	291 (72.0)		reference		reference
HLA-DRB1 shared epitope negative
RA (n = 171)	86 (50.3)	70 (40.9)	15 (8.8)	242 (70.8)	0.67	1.07 (0.80-1.43)	0.68	1.08 (0.74-1.58)
Healthy controls (n = 296)	143 (48.3)	125 (42.2)	28 (9.5)	411 (69.4)		reference		reference

OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
Association was tested by χ² analysis using 2 × 2 contingency tables. Comparisons were made between all RA and all healthy controls, HLA-DRB1 shared epitope positive RA and controls, and shared epitope negative RA and controls.
*Association was tested under the recessive model for rs7708392C allele.