| Genotype | Allele | Allelic Association | Recessive Model* | ||||
---|---|---|---|---|---|---|---|---|
 | C/C | C/G | G/G | C | P | OR (95%CI) | P | OR (95%CI) |
All RA (n = 553) | 292 (52.8) | 215 (38.9) | 46 (8.3) | 799 (72.2) | 0.23 | 1.12 (0.93-1.35) | 0.21 | 1.17 (0.92-1.49) |
All healthy controls (n = 513) | 251 (48.9) | 215 (41.9) | 47 (9.2) | 717 (69.9) | Â | reference | Â | reference |
HLA-DRB1 shared epitope positive | Â | Â | Â | Â | Â | Â | Â | |
   RA (n = 376) | 203 (54.0) | 142 (38.7) | 31 (8.2) | 548 (72.9) | 0.76 | 1.04 (0.80-1.37) | 0.57 | 1.11 (0.78-1.56) |
   Healthy controls (n = 202) | 104 (51.5) | 83 (41.1) | 15 (7.4) | 291 (72.0) |  | reference |  | reference |
HLA-DRB1 shared epitope negative | Â | Â | Â | Â | Â | Â | Â | |
   RA (n = 171) | 86 (50.3) | 70 (40.9) | 15 (8.8) | 242 (70.8) | 0.67 | 1.07 (0.80-1.43) | 0.68 | 1.08 (0.74-1.58) |
   Healthy controls (n = 296) | 143 (48.3) | 125 (42.2) | 28 (9.5) | 411 (69.4) |  | reference |  | reference |