Skip to main content

Advertisement

Table 3 Association study of TNIP1 rs7708392 with RA in a Japanese population

From: Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study

  Genotype Allele Allelic Association Recessive Model*
  C/C C/G G/G C P OR (95%CI) P OR (95%CI)
All RA (n = 553) 292 (52.8) 215 (38.9) 46 (8.3) 799 (72.2) 0.23 1.12 (0.93-1.35) 0.21 1.17 (0.92-1.49)
All healthy controls (n = 513) 251 (48.9) 215 (41.9) 47 (9.2) 717 (69.9)   reference   reference
HLA-DRB1 shared epitope positive        
   RA (n = 376) 203 (54.0) 142 (38.7) 31 (8.2) 548 (72.9) 0.76 1.04 (0.80-1.37) 0.57 1.11 (0.78-1.56)
   Healthy controls (n = 202) 104 (51.5) 83 (41.1) 15 (7.4) 291 (72.0)   reference   reference
HLA-DRB1 shared epitope negative        
   RA (n = 171) 86 (50.3) 70 (40.9) 15 (8.8) 242 (70.8) 0.67 1.07 (0.80-1.43) 0.68 1.08 (0.74-1.58)
   Healthy controls (n = 296) 143 (48.3) 125 (42.2) 28 (9.5) 411 (69.4)   reference   reference
  1. OR: odds ratio, 95% CI: confidence interval. Genotype and allele frequencies are shown in parentheses (%).
  2. Association was tested by χ2 analysis using 2 × 2 contingency tables. Comparisons were made between all RA and all healthy controls, HLA-DRB1 shared epitope positive RA and controls, and shared epitope negative RA and controls.
  3. *Association was tested under the recessive model for rs7708392C allele.