Skip to main content

Advertisement

Table 2 Association testing of six T1D associated SNPs not previously investigated for association with RA in the current cohort

From: Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease

SNP CHR position Gene MAF cases MAF controls P_HWE case_11 case_12 case_22 control_11 control_12 control_22 P_trend Allelic OR (95% CI)
rs11755527 6 91014952 BACH2 0.46 0.46 0.91 729 (20.8) 1,790 (51.0) 990 (28.2) 669 (21.5) 1,551 (49.9) 891 (28.6) 0.86 0.99 (0.93 to 1.06)
rs689 11 2138800 INS 0.28 0.28 0.54 287 (8.2) 1,411 (40.1) 1,818 (51.7) 254 (8.2) 1,246 (40.0) 1,612 (51.8) 0.95 1.00 (0.93 to 1.08)
rs12708716 16 11087374 CLEC16A 0.36 0.36 0.63 507 (12.9) 1,791 (45.4) 1,643 (41.7) 453 (12.9) 1,596 (45.5) 1,455 (41.5) 0.88 1.00 (0.93 to 1.06)
rs3825932 15 77022501 CTSH 0.32 0.32 0.77 368 (10.5) 1,506 (43.1) 1,619 (46.3) 323 (10.4) 1,366 (44.1) 1,407 (45.4) 0.62 0.98 (0.91 to 1.06)
rs3788013 21 42714397 UBASH3A 0.45 0.43 0.86 705 (20.1) 1,752 (49.9) 1,052 (30.0) 590 (19.0) 1,522 (49.0) 996 (32.0) 0.07 1.07 (1.00 to 1.14)
rs229541 22 35921264 C1QTNF6 0.45 0.43 0.49 726 (20.6) 1,693 (48.1) 1,100 (31.3) 564 (18.1) 1,548 (49.6) 1,007 (32.3) 0.04 1.08 (1.00 to 1.15)
  1. 11 = homozygote for minor allele, 12 = heterozygote, 22 = homozygote for major allele; CHR, chromosome; MAF, minor allele frequency; P_HWE, P-value for Hardy Weinberg equilibrium test