Table 2 Association testing of six T1D associated SNPs not previously investigated for association with RA in the current cohort
SNP | CHR | position | Gene | MAF cases | MAF controls | P_HWE | case_11 | case_12 | case_22 | control_11 | control_12 | control_22 | P_trend | Allelic OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs11755527 | 6 | 91014952 | BACH2 | 0.46 | 0.46 | 0.91 | 729 (20.8) | 1,790 (51.0) | 990 (28.2) | 669 (21.5) | 1,551 (49.9) | 891 (28.6) | 0.86 | 0.99 (0.93 to 1.06) |
rs689 | 11 | 2138800 | INS | 0.28 | 0.28 | 0.54 | 287 (8.2) | 1,411 (40.1) | 1,818 (51.7) | 254 (8.2) | 1,246 (40.0) | 1,612 (51.8) | 0.95 | 1.00 (0.93 to 1.08) |
rs12708716 | 16 | 11087374 | CLEC16A | 0.36 | 0.36 | 0.63 | 507 (12.9) | 1,791 (45.4) | 1,643 (41.7) | 453 (12.9) | 1,596 (45.5) | 1,455 (41.5) | 0.88 | 1.00 (0.93 to 1.06) |
rs3825932 | 15 | 77022501 | CTSH | 0.32 | 0.32 | 0.77 | 368 (10.5) | 1,506 (43.1) | 1,619 (46.3) | 323 (10.4) | 1,366 (44.1) | 1,407 (45.4) | 0.62 | 0.98 (0.91 to 1.06) |
rs3788013 | 21 | 42714397 | UBASH3A | 0.45 | 0.43 | 0.86 | 705 (20.1) | 1,752 (49.9) | 1,052 (30.0) | 590 (19.0) | 1,522 (49.0) | 996 (32.0) | 0.07 | 1.07 (1.00 to 1.14) |
rs229541 | 22 | 35921264 | C1QTNF6 | 0.45 | 0.43 | 0.49 | 726 (20.6) | 1,693 (48.1) | 1,100 (31.3) | 564 (18.1) | 1,548 (49.6) | 1,007 (32.3) | 0.04 | 1.08 (1.00 to 1.15) |