Chondromodulin (ChM)-I and vascular endothelial growth factor (VEGF) localized in cartilage at 1 month after surgery. (a, c) The defect treated with bevacizumab. (b, d) The defect in the control. (a) In the bevacizumab group, ChM-I immunostaining is detected in the interterritorial matrix of the remodeling site. (b) In the control group, ChM-I immunostaining is not detected in the remodeling site. (c, d) In both groups, VEGF immunostaining is detected in the remodeling site of the reparative cells. Bars, 100 μm in (a) and (b) and 25 μm in (c) and (d).