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Table 1 Histological grading systema

From: Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair

Tissue morphology (Ti) Intactness of calcified cartilage layer, formation of tidemark (Tide) Lateral integration of implanted material (Latl)
   4 = Mostly hyaline cartilage    1 = <25% of the calcified cartilage layer intact    1 = Not bonded
   3 = Mostly fibrocartilage    2 = 25-49% of the calcified cartilage layer intact    2 = Bonded at one end/partially both ends
   2 = Mostly noncartilage    3 = 50-75% of the calcified cartilage layer intact    3 = Bonded at both sides
   1 = Exclusively noncartilage    4 = 76-90% of the calcified cartilage layer intact Basal integration of implanted material (Basl)
Matrix staining (Matx)    5 = Complete intactness of the calcified cartilage layer    1 = <50%
   1 = None Subchondral bone formation (Bform)    2 = 50-70%
   2 = Slight    1 = No formation    3 = 70-90%
   3 = Moderate    2 = Slight    4 = 91-100%
   4 = Strong    3 = Strong Inflammation (InfH)
Structural integrity (Stru) Histologic appraisal of surface architecture (SurfH)    1 = Strong inflammation
   1 = Severe disintegration    1 = Severe fibrillation    3 = Slight inflammation
   2 = Cysts or disruption    2 = Moderate fibrillation    5 = No inflammation
   3 = No organization of chondrocytes    3 = Slight fibrillation or irregularity Histologic grading system (Hgtot)
   4 = Beginning of columnar organization of chondrocytes    4 = Normal    Some of the histologic variables:
   5 = Normal, similar to healthy mature cartilage Histologic appraisal defect filling (FilH)    Tissue morphology (Ti)
Chondrocytes clustering in implant (Clus)    1 = <25%    Matrix staining (Matx)
   1 = 25-100% of cells clustered    2 = 26-50%    Structural integrity (Stru)
   2 = <25% of the cells clustered    3 = 51-75%    Cluster formation (Clus)
   3 = No clusters    4 = 76-90%    Tidemark opening (Tide)
     5 = 91-110%    Bone formation (Bform)
      Histologic surface architecture (SurfH)
      Histologic degree of defect filling (FilH)
      Lateral integration of defect-filling tissue (Basl) and histologic signs of inflammation (InfH)
  1. aPresentation of variables and the grading system based on a modified International Cartilage Repair Society (ICRS) grading scale [26] developed by O'Driscoll, Keeley and Salter [34].
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