Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 4 | Arthritis Research & Therapy

Figure 4

From: Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis

Figure 4

╬╝CT overlays visualzing bone changes in proximal tibia from start to end of experiment. Overlaid registered longitudinal cross-section of proximal tibia scanned at start (week 0) and end of experiment (week 12) for (a) OVX+Sal mouse, (b) OVX+IA mouse, and (c) OVX+E+IA mouse. M indicates medial, L indicates lateral. Dark grey: present at both time points; black: only present at week 0 (i.e., resorbed in 12 weeks); light grey: only present at week 12 (i.e., newly formed in 12 weeks). Note the thinning of the subchondral plate (open arrowheads in (b)), loss of trabeculae in the metaphysis (both (a) and (b)), and the osteophyte formation at the medial epiphysis (closed arrowhead in (b) and (c)).

Back to article page