Cartilage damage and osteophytosis at 12 weeks postsurgery for Sham, OVX, and OVX+E groups. (a and b) Cartilage damage scored on histology using Pritzker score. (a) Patella cartilage damage. (b) Medial tibia cartilage damage. *P < 0.05 according to unpaired or paired t-test. (c) Example of patella cartilage damage and osteophytosis (arrows) on histology in an OVX+IA mouse. (d) Example of cartilage damage in medial tibia plateau. Arrows indicate surface fibrillation. (e) Example of medial knee compartment with osteophyte formation (open arrowheads). Also note glycosaminoglycan (GAG) depletion (between arrows). (f) Patella without osteophytes on micro-CT image. P = patella, F = femur. (g) Patella with osteophytes (arrows) on micro-CT image. P = patella, F = femur.