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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

Figure 3

Analysis of IL-22 and IL-23R expression on IL-17-positive CD4 T cells in PBMC and SFMC of patients with RA. A) Representative plots of the expression of IL-22 against IL-17 in CD4 T cells from isolated PBMC and SFMC are shown. B) The percentages of IL-17-positive CD4 T cells coexpressing IL-22 in PBMC from healthy donors (n = 13), paired RA PBMC and SFMC samples (n = 14) are shown. C) The frequencies of IL-22-positive CD4 T cells in HC PBMC, RA PBMC and paired SFMC are shown. D) Representative plots of the expression of IL-23R against IL-17 in CD4 T cells from isolated PBMC and SFMC are shown. E) The percentages of IL-17-positive CD4 T cells coexpressing IL-23R in PBMC from healthy donors (n = 13) and paired RA PBMC and SFMC samples (n = 11) are shown. F) The frequency of IL-23R-positive CD4 T cells was compared between healthy donor PBMC (n = 13), RA PBMC and RA SFMC (n = 11). Bars representing the median are shown within the dot plots.

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