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Table 1 Potential candidate genes common to osteoporosis and osteoarthritis

From: Genetic markers of osteoarticular disorders: facts and hopes

Adhesion molecules and ligands (e.g. integrins)

Cartilage and bone matrix proteins

Collagenic

Noncollagenic

Calciotropic hormones and their receptors

Calcitonin and calcitonin receptor

Vitamin D and vitamin D receptor

PTH and PTH receptors

Calcium-sensing receptor

Cytokines, growth factors, and their receptors (IL-6, IL-1, IGF1, etc)

Enzymes (aromatase, metalloproteinases, etc)

Sex hormones and their receptors

Androgen and androgen receptor

Estrogen and estrogen receptors

  1. IGF, insulin-like growth factor; IL, interleukin; PTH, parathyroid hormone.