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Table 2 Quantitative trait loci (QTL) associated with osteoarthritis

From: Genetic markers of osteoarticular disorders: facts and hopes

  

Region

 

Reference

QTL

affected

Phenotype

[28]

8q

GOA

Early-onset OA-CPDD (1 family)

[29]

2q23?35

Hand

Nodal OA

[30]

11q

Hip, knee

Female OA

[31]

2q

Hip, knee

OA of the hip

 

4q

 

Female OA of the hip

 

6p/6q

 

OA of the hip

 

11q

 

Female OA

 

16p/16q

 

Female OA of the hip

[32]

2q12?13

Hand

Distal interphalangeal joint OA

 

4q26?27

 

Distal interphalangeal joint OA

 

7p15?21

 

Distal interphalangeal joint OA

 

X-cen

 

Distal interphalangeal joint OA

[33]

4q35

Hip

Premature degenerative OA of the hip

[34]

6q12-13

Hip, knee

Female OA of the hip

 

6p21.3

 

Female OA of the hip

[35]

2q31

Hip, knee

Familial OA of the hip

  1. CPDD = calcium pyrophosphate deposition disease; GOA = generalized osteoarthritis; OA = osteoarthritis.