Table 3 Candidate gene polymorphisms associated with osteoarthritis
From: Genetic markers of osteoarticular disorders: facts and hopes
| Genetic | Association | ||
|---|---|---|---|
| polymorphism | Phenotype | found? | Reference |
| VDR | Female knee OA | Yes | [42] |
| Knee OA (osteophytosis) | Yes | [41] | |
| Female OA (hip replacement) | No | [50] | |
| Hand, hip, knee OA | No | [51] | |
| Idiopathic OA | No | [39] | |
| COL2A1 | PGOA/chondrodysplasia | Yes | [140] |
| Nodal GOA | No | [141] | |
| GOA, finger joints OA | No | [24] | |
| GOA | Yes | [45] | |
| Female OA (hip replacement) | No | [50] | |
| GOA | Yes | [46] | |
| Knee OA (joint space narrowing) | Yes | [47] | |
| COL1A1 | Female OA (hip replacement) | No | [50] |
| Idiopathic female OA | Yes | [39] | |
| ER a | GOA | Yes | [38] |
| Idiopathic OA | No | [39] | |
| TGFB1 | Spine OA (osteophytosis) | Yes | [48] |
| IGF-I | GOA | Yes | [44] |
| Aggrecan proteoglycan | Male bilateral hand OA | Yes | [49] |