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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation

Figure 6

Model of adrenomedullin-induced regulation of rheumatoid fibroblast-like synoviocyte (RA-FLS) adhesion by the CLR-RAMP/PKA pathway. Adrenomedullin (AM) activates RA-FLS adhesion to the extracellular matrix proteins vitronectin, fibronectin, and type I collagen. The AM-receptor antagonist (22-52)AM and silencing of RAMP-2 inhibited AM-induced RA-FLS adhesion of CLR/RAMP results in activation of PKA, as assessed by its inhibition by H-89. AM triggers a talin-β1 chain interaction, disrupting the salt bridge between the α and β subunits and thereby activating the integrins, explaining the increase in RA-FLS adhesion.

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