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Table 4 Summary of AMG 108 trough concentration (nM) at 20 and 24 weeks

From: A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

  50 mg AMG 108 125 mg AMG 108 250 mg AMG 108
  Week 20 (n= 144) Week 24 (n= 137) Week 20 (n= 146) Week 24 (n= 140) Week 20 (n= 137) Week 24 (n= 138)
Mean 0 0 16.5 19.8 155 160
Median 0 0 6.25 4.65 139 141
Range 0 to 6.43 0 to 0.32 0 to 104 0 to 268 0 to 417 0 to 1,000
  1. Below quantifiable levels reported as 0. 90% inhibitory concentration = 13.5 nM, 50% inhibitory concentration = 1.5 nM.