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Table 4 Summary of AMG 108 trough concentration (nM) at 20 and 24 weeks

From: A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis

 

50 mg AMG 108

125 mg AMG 108

250 mg AMG 108

 

Week 20 (n= 144)

Week 24 (n= 137)

Week 20 (n= 146)

Week 24 (n= 140)

Week 20 (n= 137)

Week 24 (n= 138)

Mean

0

0

16.5

19.8

155

160

Median

0

0

6.25

4.65

139

141

Range

0 to 6.43

0 to 0.32

0 to 104

0 to 268

0 to 417

0 to 1,000

  1. Below quantifiable levels reported as 0. 90% inhibitory concentration = 13.5 nM, 50% inhibitory concentration = 1.5 nM.
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Arthritis Research & Therapy

ISSN: 1478-6362

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