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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

Figure 6

PE inhibits IL-1β-induced signaling cascade in human OA chondrocytes. The MAPKs are a group of signaling molecules that include the p38-MAPKs which are activated by upstream MAPK kinases MKK3 and MKK6. In human OA chondrocytes, IL-1β through IL-1R activates preferentially MKK3 which leads to the activation of p38-MAPK → RUNX2 pathway. Polyphenols rich PE inhibited the IL-1β-induced activation of MKK# and p38-MAPK in human OA chondrocytes. Breaking lines indicate reduced phosphorylation. IL-1R, IL-1β receptor; MAPK, mitogen-activated protein kinase; MKK, MAPK kinases; MMPs, matrix metalloproteinases; p, phosphorylation; PE, pomegranate extract; RUNX2, runt-related transcription factor-2.

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