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Table 4 Changes in different variables between 3 and 24 months, using a mixed linear model

From: Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomised study over 21 months

    Pvalue
  Treatment A (n= 14) Treatment B (n= 11) Time Treatment × Compliance × Time
DAS28 -1.8 (-2.6 to -1.0) -1.9 (-2.8 to -1.0) <0.001 0.59
ESRa -0.62 (-1.07 to -0.18) -0.49 (-0.99 to 0.02) 0.003 0.78
HAQ -0.27 (-0.50 to -0.04) -0.43 (-0.69 to -0.17) <0.001 0.82
Leptina 0.25 (0.02 to 0.48) 0.32 (0.05 to 0.59) <0.001 0.07
Adiponectin 1.66 (0.16 to 3.17) 2.33 (-0.27 to 4.93) <0.001 0.058
Apolipoprotein A1 0.09 (-0.08 to 0.26) 0.19 (-0.01 to 0.39) 0.004 0.45
Apolipoprotein B -0.06 (-0.16 to 0.03) 0.07 (-0.04 to 0.18) 0.59 0.33
ApoB/ApoA1 0.09 (-0.19 to 0.00) -0.01 (-0.12 to 0.10) 0.023 0.56
P1NPa -0.02 (-0.030 to 0.25) -0.29 (-0.61 to 0.03) 0.004 0.82
CTX1a -0.25 (-0.64 to 0.14) -0.47 (-0.62 to 0.28) <0.001 0.11
1CTPa -0.05 (-0.27 to 0.16) -0.21 (-0.46 to 0.04) <0.001 0.76
P1NP/CTX-1a 0.23 (-0.04 to 0.49) -0.10 (-0.41 to 0.21) 0.023 0.08
P1NP/1CTPa 0.03 (-0.28 to 0.34) -0.08 (-0.44 to 0.28) 0.45 0.56
IGF-1a 0.06 (-0.07 to 0.18) -0.02 (-0.17 to 0.13) 0.050 0.08
IGF-1 SD score 0.32 (-0.14 to 0.78) 0.02 (-0.52 to 0.56) 0.003 0.12
  1. Data presented as mean (95% confidence interval). aArithmetic mean. Treatment A, methotrexate + sulphasalazine + hydroxychloroquine; treatment B, methotrexate +infliximab. DAS28, Disease Activity Score of 28 joints; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; apo, apolipoprotein; P1NP, procollagen type I N-terminal propeptide; CTX-1, C-terminal telopeptide of type I collagen; 1CTP, C-terminal propeptide of type I collagen; IGF-1, insulin-like growth factor-1; SD, standard deviation. Changes between 3 and 12 months and patients not compliant to respective treatment are not presented. P values given for the interactions with the main factor Time and the interactions with factor Time. Bold values are statistically significant.