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Table 2 Results of HR-pQCT variables in placebo and active group at baseline and at 12 months

From: Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid

  Placebo group Active group
Variables Baseline 12 months Change (%) P value Baseline 12 months % change p value
aBMD spine, g/cm2 0.83 (0.80, 0.90) 0.84 (0.79,0.90) 2.6 (0.03, 4.3) 0.049 0.87 (0.81,0.93) 0.89 (0.86, 0.98) 4.9 (1.7, 5.9) < 0.001
aBMD hip, g/cm2 0.75 (0.71, 0.83) 0.74 (0.71, 0.84) 0.8 (-0.9, 2.7) NS 0.76 (0.70, 0.82) 0.76 (0.73, 0.84) 1.0 (0.3, 2.5) 0.005
D100, mHA/cc 360.3 (314.2,373.8) 358.4 (313.1, 372.3) -0.1 (-1.1, 1.3) NS 332.0 (268.6, 375.1) 333.9 (269.9, 369.3) 0.5 (-0.6, 1.6) NS
Dcomp, mg HA/cc 931.9 (860.2, 962.1) 936 (866.5, 962.3) 0.45 (-0.8, 1.2) NS 901.6 (846.2, 964.6) 910.2 (857.5, 967.3) 0.6 (0.03, 1.4) 0.023
Ct. Th, mg HA/cc 0.89 (0.65, 0.96) 0.88 (0.66, 0.97) 0.0 (-1.5, 1.3) NS 0.80 (0.62, 0.95) 0.79 (0.64, 0.95) 0.7 (-1.1, 2.1) NS
Dtrab, mg HA/cc 124.6 (110.2, 146.9) 123.9 (110.5, 148.4) 0.3 (-1.4, 2.2) NS 136.4 (89.7, 150.7) 136.4 (92.6, 150.3) 1.3 (--0.3, 2.7) 0.09
Dmeta, mg HA/cc 181.4 (160.5, 209.3) 184.9 (154.5, 213.5) 0.3 (-1.1, 1.6) NS 193.9 (153.2, 211.4) 193.0 (157.7,215.1) 0.7 (-0.3, 1.8) 0.05
Dinn, mg HA/cc 90.9 (69.8, 105.8) 89.6 (71.8, 108.7) 0.9 (-2.4, 3.03) NS 88.6 (48.0, 111.6) 87.3 (50.0, 113.2) 0.5 (-1.3, 4.5) NS
BV/TV 0.10 (0.09, 0.12) 0.10 (0.09,0.12) 0.3 (-1.4, 2.2) NS 0.11 (0.08, 0.13) 0.11 (0.08, 0.13) 1.3 (-0.3,2.7) 0.08
Tb.N, 1/mm 1.49 (1.33, 1.62) 1.41 (1.29, 1.57) -3.6 (-8.9, 1.7) 0.06 1.54 (1.37, 1.62) 1.52 (1.32, 1.71) -0.3 (-4.5, 3.6) NS
Tb.Th, mm 0.07 (0.07, 0.08) 0.07 (0.07, 0.09) 2.7 (-2.5, 10.3) NS 0.07 (0.06, 0.08) 0.07 (0.06, 0.09) 0.9 (-2.3, 5.2) NS
Tb.Sp, mm 0.60 (0.54, 0.68) 0.63 (0.56,0.71) 3.9 (-1.6, 9.5) 0.04 0.57 (0.55, 0.69) 0.59 (0.52, 0.68) 0.05 (-3.8, 4.8) NS
Tb.1/N.SD, mm 0.25 (0.23, 0.28) 0.27 (0.23, 0.31) 0.65 (-2.4, 5.6) NS 0.25 (0.22, 0.30) 0.26 (0.22, 0.30) -0.15 (-1.7, 2.1) NS
  1. Values are median (IQR). aBMD, area bone mineral density; D100, average bone density; Dtrab, trabecular bone density; Dcomp, cortical bone density; Dinn, inner trabecular bone density; Dmeta, meta-trabecular bone density; Ct.Th, cortical thickness; BV/TV, trabecular bone volume to tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Tb.1/N.SD, standard deviation of 1/trabecular number; NS, not significant.