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Table 2 Results of HR-pQCT variables in placebo and active group at baseline and at 12 months

From: Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid

 

Placebo group

Active group

Variables

Baseline

12 months

Change (%)

P value

Baseline

12 months

% change

p value

aBMD spine, g/cm2

0.83 (0.80, 0.90)

0.84 (0.79,0.90)

2.6 (0.03, 4.3)

0.049

0.87 (0.81,0.93)

0.89 (0.86, 0.98)

4.9 (1.7, 5.9)

< 0.001

aBMD hip, g/cm2

0.75 (0.71, 0.83)

0.74 (0.71, 0.84)

0.8 (-0.9, 2.7)

NS

0.76 (0.70, 0.82)

0.76 (0.73, 0.84)

1.0 (0.3, 2.5)

0.005

D100, mHA/cc

360.3 (314.2,373.8)

358.4 (313.1, 372.3)

-0.1 (-1.1, 1.3)

NS

332.0 (268.6, 375.1)

333.9 (269.9, 369.3)

0.5 (-0.6, 1.6)

NS

Dcomp, mg HA/cc

931.9 (860.2, 962.1)

936 (866.5, 962.3)

0.45 (-0.8, 1.2)

NS

901.6 (846.2, 964.6)

910.2 (857.5, 967.3)

0.6 (0.03, 1.4)

0.023

Ct. Th, mg HA/cc

0.89 (0.65, 0.96)

0.88 (0.66, 0.97)

0.0 (-1.5, 1.3)

NS

0.80 (0.62, 0.95)

0.79 (0.64, 0.95)

0.7 (-1.1, 2.1)

NS

Dtrab, mg HA/cc

124.6 (110.2, 146.9)

123.9 (110.5, 148.4)

0.3 (-1.4, 2.2)

NS

136.4 (89.7, 150.7)

136.4 (92.6, 150.3)

1.3 (--0.3, 2.7)

0.09

Dmeta, mg HA/cc

181.4 (160.5, 209.3)

184.9 (154.5, 213.5)

0.3 (-1.1, 1.6)

NS

193.9 (153.2, 211.4)

193.0 (157.7,215.1)

0.7 (-0.3, 1.8)

0.05

Dinn, mg HA/cc

90.9 (69.8, 105.8)

89.6 (71.8, 108.7)

0.9 (-2.4, 3.03)

NS

88.6 (48.0, 111.6)

87.3 (50.0, 113.2)

0.5 (-1.3, 4.5)

NS

BV/TV

0.10 (0.09, 0.12)

0.10 (0.09,0.12)

0.3 (-1.4, 2.2)

NS

0.11 (0.08, 0.13)

0.11 (0.08, 0.13)

1.3 (-0.3,2.7)

0.08

Tb.N, 1/mm

1.49 (1.33, 1.62)

1.41 (1.29, 1.57)

-3.6 (-8.9, 1.7)

0.06

1.54 (1.37, 1.62)

1.52 (1.32, 1.71)

-0.3 (-4.5, 3.6)

NS

Tb.Th, mm

0.07 (0.07, 0.08)

0.07 (0.07, 0.09)

2.7 (-2.5, 10.3)

NS

0.07 (0.06, 0.08)

0.07 (0.06, 0.09)

0.9 (-2.3, 5.2)

NS

Tb.Sp, mm

0.60 (0.54, 0.68)

0.63 (0.56,0.71)

3.9 (-1.6, 9.5)

0.04

0.57 (0.55, 0.69)

0.59 (0.52, 0.68)

0.05 (-3.8, 4.8)

NS

Tb.1/N.SD, mm

0.25 (0.23, 0.28)

0.27 (0.23, 0.31)

0.65 (-2.4, 5.6)

NS

0.25 (0.22, 0.30)

0.26 (0.22, 0.30)

-0.15 (-1.7, 2.1)

NS

  1. Values are median (IQR). aBMD, area bone mineral density; D100, average bone density; Dtrab, trabecular bone density; Dcomp, cortical bone density; Dinn, inner trabecular bone density; Dmeta, meta-trabecular bone density; Ct.Th, cortical thickness; BV/TV, trabecular bone volume to tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Tb.1/N.SD, standard deviation of 1/trabecular number; NS, not significant.
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Arthritis Research & Therapy

ISSN: 1478-6362

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